REVIEW PAPER: A REAPPRAISAL OF CONCEPTS IN HEART FAILURE: CENTRAL ROLE OF CARDIAC POWER RESERVE


Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic morphine

The therapeutic benefits of opioids are compromised by the development of analgesic tolerance, which necessitates higher dosing for pain management thereby increasing the liability for drug dependence and addiction.Rodent models indicate opposing roles of the gut microbiota in tolerance: morphine-induced gut dysbiosis exacerbates tolerance, whereas

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Clustering by Partitioning around Medoids using Distance-Based Similarity Measures on Interval-Scaled Variables

It is reported in this paper, the results of a study of the partitioning around medoids (PAM) clustering algorithm applied to four datasets, both standardized and not, and of varying sizes and numbers of clusters.The angular distance proximity measure in addition to Autographed Hockey Photos the two more traditional proximity measures, namely the E

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